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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (01): 1-7.    下一篇

综述与进展

不对称合成α-氮杂环丁酮的研究进展

李耀锋，胡进勇，刘庆彬*，张占辉，张福军   

  1. (河北师范大学化学化工研究所 石家庄 050091)
  • 收稿日期:2006-11-06 修回日期:1900-01-01 发布日期:2008-01-23
  • 通讯作者: 刘庆彬

Recent Progress in the Asymmetric Synthesis of α-Azetidinones

LI Yao-Feng, HU Jin-Yong, LIU Qing-Bin*, ZHANG Zhan-Hui, ZHANG Fu-Jun   

  1. (Institute of Chemistry and Chemical Engineering, Hebei Normal University, Shijiazhuang 050091)
  • Received:2006-11-06 Revised:1900-01-01 Published:2008-01-23
  • Contact: LIU Qing-Bin

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α-氮杂环丁酮是合成培南类抗生素的母核. 作为一类具有生物活性化合物合成子的使用, 促进了其合成方法的研究. 综述了不对称合成氮杂环丁酮的研究进展, 详细讨论了氮杂环丁酮的合成方法.

关键词: 培南母核, α-氮杂环丁酮, β-内酰胺, 不对称合成

α-Azetidinones is the key intermediate of the penems antibiotics. The utility of azetidinones as synthons for various biologically active compounds has promoted to study of its synthetic methods. The progress of asymmetric synthesis of azetidinones is reviewed, and the methods for the preparation of azetidinones are discussed in detail.

Key words: α-azetidinone, penems nucleus, β-lactam, asymmetric synthesis