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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (01): 151-154. 上一篇    下一篇

研究简报

超声辐射下合成1-[(未)取代苯酰基-3-[5-(1-苯基-3-甲基-5-氯吡唑-4-基)-1,3,4-噻二唑-2-基]-硫脲

孙燕荣a，李燕萍a，刘晨江*,a,b 王吉德a,b   

  1. (a新疆大学化学化工学院 石油天然气精细化工教育部重点实验室 乌鲁木齐 830046)
    (b西安交通大学理学院 西安 710049)
  • 收稿日期:2007-02-28 修回日期:1900-01-01 发布日期:2008-01-23
  • 通讯作者: 刘晨江

Synthesis of 1-[(Un)substituted benzoyl]-3-[5-(1-phenyl-3-methyl-5- chloropyrazole-4-yl)-1,3,4-thiadiazol-2-yl]-thiourea un-derUltrasonic Radiation

SUN Yan-Ronga, LI Yan-Pinga, LIU Chen-Jiang*,a,b, WANG Ji-De a,b   

  1. (a Key Laboratory of Petroleum and Gas Fine Chemicals, Ministry of Education, College of Chemistry and
    Chemical Engineering, Xinjiang University, Ulumqi 830046)
    (b School of Sciences, Xi'an Jiaotong University, Xi'an 710049)
  • Received:2007-02-28 Revised:1900-01-01 Published:2008-01-23
  • Contact: LIU Chen-Jiang

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578

被引次数

47

1-苯基-3-甲基-5-氯吡唑-4-甲酸与氨基硫脲在三氯氧磷中反应得到2-氨基-5-(1-苯基-3-甲基-5-氯吡唑-4-基)-1,3,4-噻二唑(1), 然后分别采用超声辐射法和常规加热法与(未)取代苯甲酰基异硫氰酸酯(2)反应合成了一系列未见报到的1-[(未)取代苯酰基-3-[5-(1-苯基-3-甲基-5-氯吡唑-4-基)-1,3,4-噻二唑-2-基]-硫脲(3a～3j). 化合物的结构经元素分析, IR, 1H NMR确证.

关键词: 超声波辐射, (未)取代苯甲酰基硫脲, 1,3,4-噻二唑, 合成, 吡唑

2-Amino-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-1,3,4-thiodiazole (1) has been prepared by the reaction of 1-phenyl-3-methyl-5-chloropyrazol-4-carboxylic acid with aminothiourea in the presence of phosphorus oxychloride. Then a series of novel 1-[(un)substituted benzoyl]-3-[5-(1-phenyl-3-methyl-5- chloropyrazole-4-yl)-1,3,4-thiadiazol-2-yl]-thioureas (3a～3j) have been synthe-sized by the reaction of compound 1 with (un)substituted benzoyl isothiocyanates (2) by means of ultrasonic radiation heating method and ordinary method. The structures of these compounds were confirmed by elemental analysis, IR and 1H NMR spectra.

Key words: (un)substituted benzoylthiourea, ultrasonic radiation, 1,3,4-thiodiazole, synthesis, pyrazole