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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (01): 44-51. 上一篇    下一篇

综述与进展

糖及其衍生物作为手性助剂在立体选择性合成中的应用研究进展

傅玉琴，安雅洁，陶京朝*   

  1. (郑州大学化学系 郑州大学新药研究开发中心 郑州 450052)
  • 收稿日期:2006-08-21 修回日期:1900-01-01 发布日期:2008-01-23
  • 通讯作者: 陶京朝

Review on the Application of Carbohydrates and Their Derivatives as Chiral Auxiliaries in Stereoselective Synthesis

FU Yu-Qin, AN Ya-Jie, TAO Jing-Chao*   

  1. (Department of Chemistry, New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450052)
  • Received:2006-08-21 Revised:1900-01-01 Published:2008-01-23
  • Contact: TAO Jing-Chao

PDF

1116

被引次数

6

糖作为一类具有多官能团、多手性中心、廉价易得的手性小分子可以很方便地作为手性助剂用于不对称合成.综述了近几年来糖类化合物作为手性助剂在不对称C—C键形成反应、环氧化、手性拆分和手性识别等方面的应用研究进展.

关键词: 糖及其衍生物, 手性助剂, 不对称合成

Carbohydrate, with multi-functional groups and chiral centers in one small molecule, is inexpensive and can be converted into efficient chiral auxiliary for controlling asymmetric synthesis. The paper reviews recent progress of the application of carbohydrates as chiral auxiliaries in asymmetric synthesis including the construction of C—C bond, epoxidation, chiral resolution, chiral recognition, and etc.

Key words: chiral auxiliary, carbohydrates and their derivative, asymmetric synthesis