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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (01): 73-77. 上一篇    下一篇

研究论文

4-(色酮-3-基)-3-乙氧羰基-1,4,5,6,7,8-六氢-5-氧代-2,7,7-三甲基喹啉的一步合成

刘俊，刘罡，田晓红，曹玲华*   

  1. (新疆大学化学化工学院 乌鲁木齐 830046)
  • 收稿日期:2007-04-08 修回日期:1900-01-01 发布日期:2008-01-23
  • 通讯作者: 曹玲华

One-Pot Synthesis of 4-(Chromon-3-yl)-3-ethoxylcarbonyl-1,4,5,6,7,8-hexahydro-5-oxo-2,7,7-trimethylquinoline

LIU Jun, LIU Gang, TIAN Xiao-Hong, CAO Ling-Hua*   

  1. (College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046)
  • Received:2007-04-08 Revised:1900-01-01 Published:2008-01-23
  • Contact: CAO Ling-Hua

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629

被引次数

3

报道了用3-甲酰基色酮、5,5-二甲基-1,3-环己二酮、乙酰乙酸乙酯与醋酸铵一步法合成4-(色酮-3-基)-3-乙氧羰基-1,4,5,6,7,8-六氢-5-氧代-2,7,7-三甲基喹啉类化合物, 对其结构进行了表征, 并分析了代表性化合物2f的晶体结构. 2f晶体属于单斜晶系, P2/c空间群, 所得晶胞参数为: a＝2.0255(4) nm, b＝0.9132(2) nm, c＝1.4066(3) nm, β＝121.60(3)°, V＝2.2159(8) nm3, Z＝4, Dc＝1.335 g/cm3, μ＝0.209 mm－1, F(000)＝736, R1＝0.0556, wR2＝0.1248.

关键词: 3-甲酰基色酮, 5,5-二甲基-1,3-环己二酮, 六氢喹啉, 晶体结构

series of new 4-(chromon-3-yl)-3-ethoxylcarbonyl-1,4,5,6,7,8-hexahydro-5-oxo-2,7,7- trimethylquinoline derivatives were synthesized from substituted 3-formylchromones, 5,5-dimethyl-1,3- cyclohexadione, am-monium acetate, and ethyl acetoacetate in a one-pot reaction. The structures of these compounds were characterized. The crystal structure of compound 2f was determined by X-ray single diffraction study, which belongs to monoclinic system with space P2/c and unit cell parameters: a＝2.0255(4) nm, b＝0.9132(2) nm, c＝1.4066(3) nm, β＝121.60(3)°, V＝2.2159(8) nm3, Z＝4, Dc＝1.335 g/cm3, μ＝0.209 mm－1, F(000)＝736, R1＝0.0556, wR2＝0.1248.

Key words: 5,5-dimethyl-1,3-cyclohexadione, 3-formylchromone, hexahydroquinoline, crystal structure