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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (03): 472-475. 上一篇    下一篇

研究论文

三组分“一锅煮”合成4,5-二氢吡唑并[1,5-a]嘧啶

李明*，郭维斯，文丽荣，左正泉   

  1. (青岛科技大学化学与分子工程学院 青岛 266042)
  • 收稿日期:2006-07-28 修回日期:2007-09-26 发布日期:2008-03-18
  • 通讯作者: 李明

One-Pot Synthesis of 4,5-Dihydropyrazolo[1,5-a]pyrimidine

LI Ming*,GUO Wei-Si,WEN Li-Rong,ZUO Zheng-Quan   

  1. (College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042)
  • Received:2006-07-28 Revised:2007-09-26 Published:2008-03-18
  • Contact: LI Ming

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以芳香醛、5-氨基-1H-吡唑和丙二腈为原料, 三组分“一锅煮”合成4,5-二氢吡唑并[1,5-a]嘧啶类化合物. 所有化合物均经IR, 1H NMR和元素分析检测. 该法是一种操作简单, 产率较高的方法.

关键词: 多组分反应, 合成, 4,5-二氢吡唑并[1,5-a]嘧啶

A series of new 4,5-dihydropyrazolo[1,5-a]pyrimidine derivatives were synthesized by using al-dehydes, 5-amino-1H-pyrazole and malonitrile in one-pot. The structures of these compounds were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: synthesis, 4,5-dihydropyrazolo[1,5-a]pyrimidine, multicomponent reaction