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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (05): 881-884. 上一篇    下一篇

研究简报

水介质中三组分一锅合成1-芳基苯并[f]喹啉衍生物

张梅梅a，王香善*,a,b，李庆b，姚昌盛b，屠树江b   

  1. (a徐州师范大学 江苏省药用植物生物技术重点实验室 徐州 221116)
    (b徐州师范大学化学化工学院 徐州 221116)
  • 收稿日期:2007-07-30 修回日期:2007-10-11 发布日期:2008-05-20
  • 通讯作者: 王香善

Three-Component One-Pot Synthesis of 1-Aryl-4-benzo[f]quinoline Derivatives in Aqueous Media

ZHANG Mei-Meia,WANG Xiang-Shan*,a,b,LI Qingb
YAO Chang-Shengb,TU Shu-Jiangb   

  1. (a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou Normal Univer-sity, Xuzhou 221116)
    (b School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)
  • Received:2007-07-30 Revised:2007-10-11 Published:2008-05-20
  • Contact: WANG Xiang-Shan

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以芳醛、2-萘胺和Meldrum酸为原料, 以水为溶剂, 在回流条件下以三乙基苄基氯化铵为催化剂通过三组分一锅反应, 合成了一系列的1-芳基苯并[f]喹啉衍生物. 该方法具有反应条件温和、产率较高(79%～87%)、环境友好等优点. 产物的结构通过熔点, IR, 1H NMR和元素分析表征.

关键词: 苯并[f ]喹啉, 水, 三乙基苄基氯化铵, 合成

A series of 1-aryl-1,2-dihydrobenzo[f]quinolin-3(4H)-one derivatives were synthesized by a three-component one-pot reaction of benzaldehyde, naphthalene-2-amine and meldrum’s acid at refluxing temperature catalyzed by triethylbenzylammonium chloride in water. This method has the advantages of milder reaction conditions, good yields (79%～87%) and environmental benignity. The structures of the products were characterized by melting points, IR, 1H NMR spectra and elemental analysis.

Key words: water, triethylbenzylammonium chloride, synthesis, benzo[f]quinoline