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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (05): 914-917. 上一篇    下一篇

研究简报

无溶剂无催化剂条件下芳香醛与3-甲基异噁唑-5-酮的缩合反应

张英群*，王春，张美月，崔朋雷，李越敏
周欣，李敬慈   

  1. (河北农业大学理学院 保定 071001)
  • 收稿日期:2007-09-30 修回日期:2007-10-19 发布日期:2008-05-20
  • 通讯作者: 张英群

Condensation Reactions of Aromatic Aldehydes with 3-Methyl-4,5- dihydroisoxazol-5-one without Solvent and Catalyst

ZHANG Ying-Qun*,WANG Chun,ZHANG Mei-Yue,CUI Peng-Lei
LI Yue-Min,ZHOU Xin,LI Jing-Ci   

  1. (College of Science, Agricultural University of Hebei, Baoding 071001)
  • Received:2007-09-30 Revised:2007-10-19 Published:2008-05-20
  • Contact: ZHANG Ying-Qun

PDF

1387

被引次数

6

在无溶剂无催化剂条件下, 芳香醛与3-甲基异噁唑-5-酮经室温研磨和固相加热发生缩合反应得到了系列3-甲 基-4-芳亚烃基异噁唑-5-酮. 产物的结构经1H NMR, IR, MS和元素分析确证.

关键词: 缩合, 3-甲基异噁唑-5-酮, 3-甲基-4-芳亚烃基异噁唑-5-酮, 无溶剂, 盐酸羟胺, 芳香醛, 乙酰乙酸乙酯

A series of 4-arylmethylidene-3-methyl-4,5-dihydroisoxazol-5-one derivatives were synthesized by the condensation reactions of aromatic aldehydes with 3-methyl-4,5-dihydroisoxazol-5-one via room temperature grinding or heating under solvent-free conditions without any catalyst. The products were identified by 1H NMR, IR, MS spectra and elemental analysis.

Key words: 4-arylmethylidene-3-methyl-4,5-dihydroisoxazol-5-one, condensation, ethyl acetoacetate, hydroxylamine hydrochloride, solvent-free, aromatic aldehyde, 3-methyl-4,5-dihydroisoxazol-5-one