有机化学 ›› 2008, Vol. 28 ›› Issue (08): 1428-1432. 上一篇    下一篇

研究论文

β-榄香烯烃基硒醚的一锅法合成

尹红星a; 张殊佳 a,b ; 郑学仿*,b; 杨兰义a   

  1. (a大连大学环境与化学工程学院 大连 116622)
    (b大连大学辽宁省生物有机化学重点实验室 大连 116622)
  • 收稿日期:2008-01-24 修回日期:2008-03-11 发布日期:2008-08-18
  • 通讯作者: 郑学仿

One-Pot Synthesis of β-Elemene-13-yl Alkyl Selenides

YIN, Hong-Xing a; ZHANG, Shu-Jia a,b; ZHENG, Xue-Fang*,b ; YANG, Lan-Yia   

  1. (a College of Environment and Chemical Engineering, Dalian University, Dalian 116622)
    (b Liaoning Key Laboratory of Bioorganic Chemistry, Dalian University, Dalian 116622)
  • Received:2008-01-24 Revised:2008-03-11 Published:2008-08-18
  • Contact: ZHENG, Xue-Fang


常温下将硒用N2H4•H2O还原后与卤代烃反应得到对称二硒醚, 不经分离直接用NaBH4还原, 再与13-氯-β-榄香烯作用得到β-榄香烯烃基硒醚. 此一锅法操作简便、条件温和、反应快速而且产率较高, 是合成不对称硒醚的一种简便实用的方法. 对化合物g的初步生物活性实验表明其具有显著的抗氧化作用.

关键词: b-榄香烯, 不对称硒醚, 抗氧化作用, 一锅法

A convenient and efficient procedure is described for the preparation of β-elemene-13-yl alkyl selenides by treatment of selenium with N2H4•H2O/RX/NaBH4/13-chloro-β-elemene sequentially in one-pot at room temperature. This method has several advantages such as simple operation, short reaction time, mild conditions and high yields. It also provides a convenient and efficient way to the synthesis of unsymmetrical dialkyl selenides. The preliminary bioassay showed that product g exhibited notable antioxidation activity.

Key words: β-elemene, one-pot procedure, antioxidation, unsymmetrical selenide