SIOC English
有机化学
高级检索

有机化学 ›› 2008, Vol. 28 ›› Issue (11): 1989-1992. 上一篇    下一篇

研究简报

微波辐射下合成2-(未)取代苯甲酰胺基-5-(1-苯基-3-甲基-5-氯吡唑- 4-基)-1,3,4-噻二唑衍生物

孙燕荣a ; 李燕萍a ; 糟新民a; 刘晨江*,a,b; 王吉德a,b   

  1. (a 新疆大学化学化工学院 石油天然气精细化工教育部重点实验室 乌鲁木齐 830046)
    (b 西安交通大学理学院 西安 710049)
  • 收稿日期:2007-11-06 修回日期:2008-05-06 发布日期:2008-11-18
  • 通讯作者: 刘晨江

Synthesis of 2-(Un)substituted Benzamido-5-(1-phenyl-3-methyl-5- chloropyrazol-4-yl)-1,3,4-thiadiazole Derivatives under Microwave Radiation

SUN, Yan-Rong a; LI, Yan-Ping a;ZAO, Xin-Min a; LIU, Chen-Jiang*,a,b ; WANG, Ji-De a,b
  

  1. (a Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, College of Chemistry and
    Chemical Engineering, Xinjiang University, Urumqi 830046)
    (b School of Sciences, Xi’an Jiaotong University, Xi’an 710049)
  • Received:2007-11-06 Revised:2008-05-06 Published:2008-11-18
  • Contact: LIU, Chen-Jiang

PDF

1251

被引次数

4 | 1

分别在微波辐射和常规加热条件下, 通过2-氨基-5-(1-苯基-3-甲基-5-氯吡唑-4-基)-1,3,4-噻二唑(1)与(未)取代苯甲酰氯(2a～2j)反应, 合成了一系列未见文献报道的2-(未)取代苯甲酰胺基-5-(1-苯基-3-甲基-5-氯吡唑-4-基)-1,3,4-噻二唑衍生物(3a～3j). 标题化合物的结构经元素分析, IR, 1H NMR确证.

关键词: 1,3,4-噻二唑, 吡唑, 合成, 微波辐射

A series of novel 2-(un)substituted benzamido-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-
1,3,4-thiadiazole derivatives (3a～3j) have been synthesized by the reaction of 2-amino-5-(1-phenyl-3-
methyl-5-chloropyrazol-4-yl)-1,3,4-thiadiazole (1) with (un)substituted benzoylchlorides (2a～2j) under a microwave radiation condition and an ordinary heating condition. The structures of these compounds were confirmed by elemental analysis, IR and 1H NMR spectra.

Key words: 1,3,4-thiadiazole, pyrazole, synthesis, microwave radiation