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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (12): 2126-2131. 上一篇    下一篇

研究论文

异黄酮类化合物的合成新方法

戴立言* ; 王晓钟; 陈英奇   

  1. (浙江大学材料与化工学院制药工程研究所 杭州 310027)
  • 收稿日期:2008-02-27 修回日期:2008-05-13 发布日期:2008-12-28
  • 通讯作者: 戴立言

A New Synthetic Approach to Isoflavones

DAI, Li-Yan*; WANG, Xiao-Zhong; CHEN, Ying-Qi   

  1. (a Institute of Pharmaceutical Engineering, College of Materials Science and Chemical Engineering,
    Zhejiang University, Hangzhou 310027)
  • Received:2008-02-27 Revised:2008-05-13 Published:2008-12-28
  • Contact: DAI, Li-Yan

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被引次数

29 | 2

提出了一种新颖的合成异黄酮类化合物1, 2和3的方法. 以1,3-二甲氧基苯或1,3,5-三甲氧基苯为原料, 经Hoesch反应或Friedel-Crafts酰化反应、脱甲基反应、增碳关环一系列反应得到关键的甲氧基异黄酮化合物, 然后甲氧基异黄酮经过不同浓度氢溴酸的选择性水解反应制得含一个或多个羟基的异黄酮类化合物.

关键词: 异黄酮, 合成, 甲氧基异黄酮, 羟基异黄酮, 脱氧安息香

A simple and new synthetic approach to isoflavones 1, 2 and 3 was described. This method was started from 1,3-dimethoxybenzene or 1,3,5-trimethoxybenzene via a synthetic sequence of Hoesch reaction or Friedel-Crafts acylation, demethylation and cyclization to obtain common key intermediate methoxy-isoflavones. Selective hydrolysis of the methoxyisoflavones gave isoflavones 1, 2 and 3, respectively with one or more hydroxyl groups.

Key words: methoxyisoflavone, isoflavone, hydroxyisoflavone, synthesis, deoxybenzoin