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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (2): 181-186. 上一篇    下一篇

综述与进展

铜络合物催化的格氏试剂不对称1,4-共轭加成反应研究进展

汪顺义，纪顺俊*   

  1. (苏州大学化学化工学院 江苏省有机合成重点实验室 苏州 215123)
  • 收稿日期:2007-01-16 修回日期:2007-05-21 发布日期:2008-02-01
  • 通讯作者: 纪顺俊

Recent Progress in Asymmetric 1,4-Conjugate Addition ofGrignard Reagents

WANG Shun-Yi,JI Shun-Jun*   

  1. (Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineer-ing,
    Suzhou University, Suzhou 215123)
  • Received:2007-01-16 Revised:2007-05-21 Published:2008-02-01
  • Contact: JI Shun-Jun

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1507

被引次数

6

铜络合物催化的有机金属试剂与α,β-不饱和羰基化合物的1,4-共轭加成反应, 是形成新的C—C键的重要方法之一. 介绍了铜络合物催化的格氏试剂与α,β-不饱和羰基化合物的立体选择性1,4-共轭加成反应的研究进展.

关键词: 格氏试剂, 立体选择性, 1,4-共轭加成, 手性催化剂, 铜络合物

The copper-catalyzed conjugate addition of organometallic reagents to α,β-unsaturated car-bonyl compounds is one of the most versatile synthetic methods for the construction of C—C bonds. This review summarizes recent advance in the enantioselectivity of 1,4-conjugate addition of Grignard reagents to α,β-unsaturated carbonyl compounds.

Key words: enantioselective, Grignard reagent, 1,4-conjugate addition, chiral catalyst, copper-complex