有机化学 ›› 2008, Vol. 28 ›› Issue (9): 1501-1514.    下一篇

综述与进展

具有生理活性的含氧、氮、硫杂原子螺环化合物的研究进展

魏荣宝* ; 刘 博; 刘 洋; 郭金晶; 张大为   

  1. 天津理工大学化学化工学院 天津 300191
  • 收稿日期:2007-06-30 修回日期:2008-12-06 发布日期:2008-09-20
  • 通讯作者: 魏荣宝

Progress in the Studies on Biological Activities of O, N or S-Containing Spiro Compounds

WEI, Rong-Bao* ; LIU, Bo; LIU, Yang; GUO, Jin-Jing; ZHANG, Da-Wei   

  1. College of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300191)
  • Received:2007-06-30 Revised:2008-12-06 Published:2008-09-20
  • Contact: wrb_111@126.com

综述了近年来部分具有生理活性螺环化合物的研究进展, 重点介绍了这类化合物的结构特征、生理活性和部分化合物的合成方法. 展望了该类螺环化合物的应用前景.

关键词: 螺环化合物, 生理活性, 手性轴, 医药

The recent progress in the studies on biological activities of O, N or S-containing spiro compounds is reviewed. The spiro compounds of structural feature and biological activities are described in detail and the synthetic methods of some spiro organic compounds are also provided. At last the prospects of this kind of spiro compounds are made.

Key words: spiro-compound, pharmaceutical, chiral axis, biological activity