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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (9): 1641-1645. 上一篇    下一篇

研究简报

1-(2-苯并呋喃酰基)愈创兰烃薁的合成

王道林*; 韩 珊; 谷 峥 ; 徐 姣   

  1. (渤海大学化学化工学院 辽宁省应用化学重点实验室 锦州 121003)
  • 收稿日期:2007-12-26 修回日期:2008-03-27 发布日期:2008-09-20
  • 通讯作者: 王道林

Synthesis of 1-(2-Benzo[b]furoyl)guaiazulene Derivatives

WANG, Dao-Lin*; HAN, Shan; GU, Zheng; XU, Jiao   

  1. (Liaoning Key Laboratory of Applied Chemistry, College of Chemistry and Chemical Engineering,
    Bohai University, Jinzhou 121003)
  • Received:2007-12-26 Revised:2008-03-27 Published:2008-09-20
  • Contact: WANG, Dao-Lin

PDF

1585

被引次数

18

在路易斯酸作用下, 以氯乙酰氯为酰基化试剂, 对愈创兰烃薁进行了酰化反应研究, 将氯乙酰化产物与水杨醛在温和反应条件下进行缩合, 以较好的收率、高选择性地得到1-(2-苯并[b]呋喃酰基)兰烃薁类衍生物, 其结构经1H NMR, IR及元素分析等得以证实.

关键词: 合成, 薁, 水杨醛, 愈创兰烃薁, 氯乙酰化反应, 苯并[b]呋喃

1-(2-Benzo[b]furoyl)guaiazulene derivatives were synthesized by the condensation of 3-(chloroacetyl)guaiazulene with salicylaldehydes under mild conditions with good yields. The chloroacety-lation conditions of guaiazulene with chloroacetyl chloride were discussed. All the compounds were fully characterized by 1H NMR, IR spectra and elemental analysis.

Key words: azulene, chloroacetylation, salicylaldehyde, synthesis, guaiazulene, benzo[b]furan