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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (01): 123-127. 上一篇    下一篇

研究简报

新型含2-取代-1,3-噻唑烷和噻唑环的亚胺类化合物的合成及生物活性

戴 红; 刘建兵 ; 张 欣; 于海波; 秦 雪;
秦振芳 ; 王婷婷; 方建新*
  

  1. (南开大学元素有机化学国家重点实验室 天津市农药科学重点实验室 天津 300071)
  • 收稿日期:2008-09-27 修回日期:2008-11-20 发布日期:2009-01-20
  • 通讯作者: 方建新

Synthesis and Biological Activities of Novel Imine Derivatives Containing 2-Substituted-1,3-thiazolidine and Thiazole Rings

Dai, Hong; Liu, Jianbing ; Zhang, Xin ; Yu, Haibo ; Qin, Xue;
Qin, Zhenfang ; Wang, Tingting ; Fang, Jianxin*
  

  1. (State Key Laboratory of Elemento-organic Chemistry and Tianjin Key Laboratory of Pesticide Science,
    Nankai University, Tianjin 300071)
  • Received:2008-09-27 Revised:2008-11-20 Published:2009-01-20
  • Contact: Fang, Jianxin

PDF

1367

被引次数

26 | 10

通过4-[(2-氰基亚胺基-1,3-噻唑烷-3-基)甲基]-2-氨基噻唑与取代苯甲醛的缩合反应, 合成了14个新型含2-取代- 1,3-噻唑烷和噻唑环的亚胺类化合物5. 所有化合物的结构均经1H NMR和元素分析确证, 并通过X射线单晶衍射分析测定了化合物5a的晶体结构. 初步生物活性试验结果表明, 部分目标化合物具有一定的杀菌活性和植物生长调节活性.

关键词: 2-取代-1,3-噻唑烷, 噻唑, 生物活性, 亚胺, 合成

Fourteen new imine derivatives 5 containing 2-substituted-1,3-thiazolidine and thiazole rings were synthesized by the condensation of 2-cyanoimino-3-(2-aminothiazol-4-ylmethyl)thiazolidine with various substituted benzaldehydes. The structures of the title compounds were characterized by 1H NMR spectra and elemental analysis. The structure of 5a was also determined by X-ray diffraction analysis. Preliminary bioassay showed that some of the target compounds exhibited fungicidal and plant growth regulatory activities to some extent.

Key words: thiazole, 2-substituted-1,3-thiazolidine, imine, biological activity, synthesis