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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (02): 245-251. 上一篇    下一篇

研究论文

取代1,2,4-三唑并[1,5-c]嘧啶衍生物的合成与生物活性

陈超南 ; 陈 琼*; 杨光富   

  1. (华中师范大学化学学院农药与化学生物学教育部重点实验室 武汉 430079)
  • 收稿日期:2008-02-28 修回日期:2008-05-29 发布日期:2009-02-20
  • 通讯作者: 陈 琼

Synthesis and Biological Activity of Substituted 1,2,4-Triazolo[1,5-c]pyrimidine Derivatives

Chen, Chaonan; Chen, Qiong*; Yang, Guangfu   

  1. (Key Laboratory of Pesticide & Chemical Biology, Education of Ministry, College of Chemistry,
    Central China Normal University, Wuhan 430079, China)
  • Received:2008-02-28 Revised:2008-05-29 Published:2009-02-20
  • Contact: Chen, Qiong

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1255

被引次数

12

以肼基取代嘧啶为起始原料, 设计合成了16个新型的5-甲硫基-7-氯-1,2,4-三唑并[1,5-c]嘧啶-2-氧苄醚类及35个取代1,2,4-三唑并[1,5-c]嘧啶-2-氧苯醚类化合物, 通过元素分析、MS和1H NMR对所合成的化合物进行了结构表征. 初步生测结果表明, 部分化合物表现出不同程度的除草及杀菌活性.

关键词: 1,2,4-三唑并[1,5-c]嘧啶, 合成, 生物活性

Sixteen novel 2-[substituted benzyloxy 7-chloro-5-methylsulfanyl-[1,2,4]-triazolo[1,5-c] pyrimidine derivatives and thirty-six novel substituted 2-phenoxy-[1,2,4]-triazolo[1,5-c]pyrimidine deriva- tives have been designed and synthesized using substituted 4-hydrazinopyrimidine as starting material. All synthesized compounds were confirmed by elemental analysis, MS and 1H NMR techniques. Preliminary bioassay indicates that some of them display good herbicidal and fungicidal activities.

Key words: synthesis, biological activity, 1,2,4-triazolo[1,5-c]pyrimidine