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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (03): 392-395. 上一篇    下一篇

研究论文

芳基乙酮酸乙酯的合成新方法

向纪明a,b; 陈久存b ; 李宝林*,a   

  1. (a陕西师范大学化学与材料学院 教育部药用植物资源与天然药物化学重点实验室 西安 710062)
    (b安康学院化学系 安康 725000)
  • 收稿日期:2007-10-31 修回日期:2008-01-28 发布日期:2009-03-20
  • 通讯作者: 李宝林

A New Way to Synthesis of Ethyl Arylglyoxylates

Xiang, Jiming a,b; Chen, Jiucun b; Li, Baolin*,a   

  1. (a Key Laboratory of Medicinal Plant Resource & Natural Pharmaceutical Chemistry, Ministry of Education,
    School of Chemistry and Materials Science, Shaanxi Normal University, Xi’an 710062)
    (b Department of Chemistry, Ankang University, Ankang 725000)
  • Received:2007-10-31 Revised:2008-01-28 Published:2009-03-20
  • Contact: Li, Baolin

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被引次数

36 | 7

以芳烃和草酰氯单乙酯为原料, 采用Friedel-Crafts酰基化反应合成了8种芳基乙酮酸乙酯, 用IR, 1H NMR, 元素分析确认了合成化合物结构, 并用高效液相色谱法分析了反应的选择性. 此合成方法具有反应条件温和、操作简单、产率高的特点.

关键词: 芳基乙酮酸乙酯, 酰基化反应, 合成

By the Friedel-Crafts acylation reaction with aromatic compounds 1a～1h and ethyl oxalyl chloride as the starting materials, eight ethyl arylglyoxylates 2a～2h have been synthesized, and their structures were confirmed by IR, 1H NMR spectra and elemental analyses. The regioselectivity of the reaction was studied by high performance liquid chromatography. This synthetic method provides several advantages such as mild reacting-conditions, simple workup procedures and high yields.

Key words: acylation reaction, synthesis, ethyl arylglyoxylate