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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (03): 444-449. 上一篇    下一篇

研究简报

2-烷基-6-甲氧基-1,4-苯醌的全合成

武利强* ; 杨春广; 杨利敏 ; 杨丽娟   

  1. (新乡医学院药学院 新乡 453003)
  • 收稿日期:2008-05-04 修回日期:2008-08-18 发布日期:2009-03-20
  • 通讯作者: 武利强

Total Synthesis of 2-Alkyl-6-methoxy-1,4-benzoquinones

Wu, Liqiang*; Yang, Chunguang; Yang, Limin; Yang, Lijuan   

  1. (School of Pharmacy, Xinxiang Medical College, Xinxiang 453003)
  • Received:2008-05-04 Revised:2008-08-18 Published:2009-03-20
  • Contact: Wu, Liqiang

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被引次数

1

3,5-二甲氧基苯甲醛经格氏、氧化反应制到3,5-二甲氧基苯基烷基酮, 然后在微波辐射下经黄鸣龙还原和选择性脱甲基化、Teuber氧化反应制得目标化合物, 产率均在50%以上. 产物结构经IR, 1H NMR, 元素分析等进行了表征.

关键词: 合成, 微波辐射, 2-烷基-6-甲氧基-1,4-苯醌, 黄鸣龙还原

2-Alkyl-6-methoxy-1,4-benzoquinones were synthesized from 3,5-dimethoxybenzaldehyde by Grignard and oxidizing reaction to give 3,5-dimethoxyphenylalkylketones, followed by selective demethylation and Huang Minglong reduction under microwave irradiation, and Teuber oxidizing reaction in good yields. All products were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: 2-alkyl-6-methoxy-1,4-benzoquinone, Huang Minglong reduction, synthesis, microwave irradiation