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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (03): 454-458. 上一篇    下一篇

研究简报

1-取代哌啶-4-酮肟醚的合成与杀菌活性测定

尹安琴a ; 薛思佳*,a ; 方治坤a; 陈 龙a ; 胥 杨a   

  1. (a上海师范大学生命与环境科学学院化学系 上海 200234)
  • 收稿日期:2008-06-23 修回日期:2008-10-09 发布日期:2009-03-20
  • 通讯作者: 薛思佳

Synthesis and Antifungal Activity of 1-Substituted Piperidin-4-one Oxime Ether

Yin, Anqin a; Xue, Sijia*,a; Fang, Zhikun a; Chen, Longa ; Xu, Yanga   

  1. (College of Life and Environment Science, Shanghai Normal University, Shanghai 200234)
  • Received:2008-06-23 Revised:2008-10-09 Published:2009-03-20
  • Contact: Xue, Sijia

PDF

1245

被引次数

7 | 1

以取代苄胺或苯乙胺为起始原料, 依次经Michael 加成, Dieckmann缩合, 水解脱羧, 肟化和醚化等多步反应合成了11个未见文献报道的1-取代哌啶-4-酮肟醚5a～5k. 目标化合物的结构经元素分析, IR, 1H NMR和MS测定确证. 初步杀菌活性测试表明, 部分化合物有较好的杀菌活性.

关键词: 杀菌活性, 1-取代-4-哌啶酮, 肟醚, 合成

Eleven unreported 1-substitutedpiperidin-4-one oxime ethers 5a～5k were synthesized with (un)substituted benzylamines or phenethylamine as raw materials via a series of Michael addition, Dieckmann condensation, hydrolysis decarboxylation reactions, oximation and etherification. The structures of all newly synthesized compounds were elucidated and confirmed by elemental analysis, IR, 1H NMR and MS techniques. The preliminary antifungal activity tests show that some of the target compounds have good antifungal activities.

Key words: oxime ether, synthesis, antifungal activity, 1-substituted piperidin-4-one