有机化学 ›› 2009, Vol. 29 ›› Issue (03): 459-461. 上一篇    下一篇

研究简报

3-取代吲哚酮类化合物的合成及抗癌活性研究

肖 锋 ; 罗 宇* ; 吕 伟 汤 杰   

  1. (华东师范大学化学系药物化学研究所 上海 200062)
  • 收稿日期:2008-05-14 修回日期:2008-08-10 发布日期:2009-03-20
  • 通讯作者: 罗 宇

Synthesis and Antitumor Evaluation of 3-Substituted Indolin-2-ones

Xiao, Feng; Luo, Yu*; Lü, Wei ; Tang, Jie   

  1. (Institute of Medicinal Chemistry, Department of Chemistry, East China Normal University, Shanghai 200062)
  • Received:2008-05-14 Revised:2008-08-10 Published:2009-03-20
  • Contact: Luo, Yu

设计合成了9种未见报道的3-取代吲哚酮类化合物, 所有目标化合物的结构经1H NMR, IR, MS, 元素分析表征确证. 初步的生物学活性研究结果表明, 此类化合物对HL-60细胞系的增殖具有一定的抑制作用.

关键词: 抗癌活性, 合成, 脲, 吲哚酮

Nine novel 3-substituted indolin-2-one derivatives were designed and synthesized. Structures of all target compounds were confirmed by 1H NMR, MS, IR spectra and elemental analysis. Preliminary biological test indicated that the compounds exhibited some inhibitory activity against the HL-60 cell lines.

Key words: antitumor activity, synthesis, urea, indolin-2-one