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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (05): 696-702. 上一篇    下一篇

综述与进展

β-氨基酸的合成: 等当体方法的应用

邓光辉a; 王 江a; 林岱宗a ; 张小栋a ; 蒋华良a,b; 柳 红*,a   

  1. (a中国科学院上海药物研究所 新药研究国家重点实验室药物设计和发现中心 上海 201203)
    (b华东理工大学药学院 上海 200237)
  • 收稿日期:2008-07-04 修回日期:2008-09-28 发布日期:2009-05-20
  • 通讯作者: 柳 红

Synthesis of β-Amino Acid—The Applications of β-Amino Acid Equivalents

Deng, Guanghuia ; Wang, Jianga; Lin, Daizonga ; Zhang, Xiaodonga ;
Jiang, Hualiang a,b; Liu, Hong*,a
  

  1. (a Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica,
    Chinese Academy of Sciences, Shanghai 201203)
    (b School of Pharmacy, East China University of Science and Technology, Shanghai 200237)
  • Received:2008-07-04 Revised:2008-09-28 Published:2009-05-20
  • Contact: Liu, Hong

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β-氨基酸是一类在药物开发和生物研究中有广泛应用的中间体. 由等当体合成β-氨基酸的方法具有结构定制、合成产物丰富、直观等特点, 是β-氨基酸合成领域中不可或缺的合成方法. 重点介绍近年来该领域具有代表性的工作.

关键词: 等当体, 合成, β-氨基酸

β-Amino acids play important roles in the field of modern medical intermediates and protein biology. The method for synthesis of β-amino acid through equivalents, featuring tailor making, versatile, and direct characteristics, has attracted considerable attention. This manuscript focuses on recent important progress in this field.

Key words: equivalent, synthes, β-amino acid