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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (10): 1508-1521. 上一篇    下一篇

综述与进展

具有生理活性的天然螺缩酮化合物研究进展

魏荣宝* 李文丽 刘 博 梁 娅   

  1. 天津理工大学化学化工学院 天津 300191
  • 收稿日期:2008-08-16 修回日期:2008-12-25 发布日期:2009-03-12

Progress in the Studies on Biological Activities of Natural Spiroketal Compounds

Wei, Rongbao* Li, Wenli Liu, Bo Liang, Ya   

  1. College of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300191
  • Received:2008-08-16 Revised:2008-12-25 Published:2009-03-12

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2326

被引次数

5

螺缩酮类化合物广泛存在于自然界中, 它们表现出的很好的生理活性已引起各国科学家的兴趣. 对近年来天然存在的螺缩酮化合物的研究进展进行了总结, 描述了这类化合物的结构特征, 展望了在医药、农药等方面的潜在发展前景.

关键词: 螺缩酮化合物, 生理活性, 异头效应, 手性轴

Spiro-ketal compounds enjoy widespread occurrence as substructures of naturally occurring substances from many sources, including insects, microbes, plants and marine organisms. The increasing pharmacological importance of such compounds containing spiro-ketal assemblies has triggered intense interest in both their synthesis and chemical reactivity. The recent progress in the studies on the spiro-ketal compounds is reviewed. Their structural features are described in detail and the synthetic methods of some spiro organic compounds are also provided. At last the prospects of this kind of spiro compounds in medicine and pesticide are made.

Key words: spiro-ketal compound, physiological activity, anomeric effect, chiral axis