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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (11): 1708-1718. 上一篇    下一篇

综述与进展

咪唑并吡啶化合物的合成研究进展

周建良a   刘建超a,b   陈启元*,a   

  1. (a中南大学化学化工学院 长沙 410083) (b华中师范大学化学学院 武汉 430079)
  • 收稿日期:2008-09-29 修回日期:2008-12-10 发布日期:2009-04-15
  • 通讯作者: 刘建超 E-mail:journal@mail.ccnu.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

Advances in Synthesis of Imidazopyridine Derivatives

Zhou, Jianlianga   Liu, Jianchao a,b   Chen, Qiyuan*,a   

  1. (a College of Chemistry and Chemical Engineering, Central South University, Changsha 410083) (b College of Chemistry, Central China Normal University, Wuhan 430079)
  • Received:2008-09-29 Revised:2008-12-10 Published:2009-04-15

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咪唑并吡啶类化合物是一类非常重要的含氮稠杂环化合物, 在医药、农药和染料工业有着广泛的应用. 该类化合物由于其特定的生理活性以及和吲哚、氮杂吲哚等在结构上的类似性, 引起了人们广泛的兴趣. 常见的咪唑并吡啶类化合物有咪唑并[1,2-a]吡啶、咪唑并[1,5-a]吡啶、咪唑并[4,5-b]吡啶和咪唑并[4,5-c]吡啶等类型. 以咪唑并[1,2-a]吡啶和咪唑并[1,5-a]吡啶化合物为例, 阐述该类化合物近十年来的合成研究进展.

关键词: 咪唑并吡啶, 杂环化合物, 合成

Imidazopyridine derivatives are of great importance because of their remarkable biological properties. They are of chemical and pharmacological interest due to their isosterism with indoles and azaindoles, two im-portant heterocycles involved in many alkaloids. Some of them have been used as herbicides, fungicides, pesticides, medicines and dyes. The imidazopyridines comprise four isomers: imidazo[1,2-a]- pyridine, imidazo[1,5-a]pyridine, imidazo[4,5-b]pyridine, and imidazo[4,5-c]pyridine. This paper reviews the advances in the synthesis of imidazopyridine derivatives during the past ten years.

Key words: imidazopyridine derivative, heterocyclic compound, synthesis