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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (11): 1811-1815. 上一篇    下一篇

研究论文

水介质中1,4-二芳基喹啉-2,5-二酮衍生物的绿色合成

张梅梅a     李 庆b       吴健蓉b       王香善*,a,b   

  1. (a徐州师范大学江苏省药用植物生物技术重点实验室 徐州 221116) (b徐州师范大学化学化工学院 徐州221116)
  • 收稿日期:2009-02-22 修回日期:2009-05-21 发布日期:2009-06-26
  • 通讯作者: 王香善 E-mail:xswang@xznu.edu.cn
  • 基金资助:

    国家自然科学基金(20802061);江苏省高校自然科学基金资助项目(08KJD150019)

A Clean Synthesis of 1,4-Diarylquinoline-2,5-dione Derivatives in Aqueous Media

Zhang, Meimeia      Li, Qingb       Wu, Jianrongb       Wang, Xiangshan*,a,b   

  1. (a Key Laboratory of Biotechnology on Medical Plant of Jiangsu Province, Xuzhou Normal University, Xuzhou 221116) (b School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116)
  • Received:2009-02-22 Revised:2009-05-21 Published:2009-06-26

PDF

1277

被引次数

7

以芳醛、3-芳氨基-5,5-二甲基环己-2-烯酮和Meldrum酸为原料, 以水为溶剂, 在回流条件下以三乙基苄基氯化铵为催化剂通过三组分一步反应, 合成了一系列的7,7-二甲基-1,4-二芳基-1,2,3,4,5,6,7,8-八氢化喹啉-2,5-二酮衍生物. 该方法具有中性反应条件、产率高(80 %～92 %)、操作简单和环境友好等优点.

关键词: 喹啉, 水, 三乙基苄基氯化铵, 合成

A series of 7,7-dimethyl-1,4-diaryl-1,2,3,4,5,6,7,8-octahydroquinoline-2,5-dione derivatives were synthesized in high yields by a three-component reaction of 3-arylamino-5,5-dimethylcyclohex-2- enones, aromatic aldehydes and Meldrum’s acid catalyzed by triethylbenzylammmonium chloride (TEBAC) at reflux in aqueous media. This method had several advantages of neutral reaction conditions, high yields, simple work-up and environmental benignity.

Key words: quinoline, water, TEBAC, synthesis