有机化学 ›› 2010, Vol. 30 ›› Issue (01): 79-84. 上一篇    下一篇

研究论文

新型β-二酚卟啉光敏剂合成及其与DNA作用

黄齐茂,李志远,肖 欣,潘志权*,邓鹏星   

  1. (武汉工程大学化工与制药学院 绿色化工过程省部共建教育部重点实验室 武汉 430073)
  • 收稿日期:2009-05-16 修回日期:2009-06-30 发布日期:2010-01-20
  • 通讯作者: 黄齐茂 E-mail:huangqim@163.com
  • 基金资助:

    国家自然科学基金(批准号:20471045); 湖北省自然科学基金青年杰出人才项目(批准号: 2008CDB072);国家级.国家自然科学基金

Synthesis of Novel β-Dihydroxyarylporphyrins and Their Interaction with DNA

Huang,Qimao,Li ,Zhiyuan,Xiao,Xin,Pan,Zhiquan*,Deng,Pengxing   

  1. (Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology,Wuhan 430073)
  • Received:2009-05-16 Revised:2009-06-30 Published:2010-01-20

以β-硝基卟啉为原料,分别与2,3-萘二酚或邻苯二酚直接反应,制备了6个新型β-二酚取代卟啉光敏药物,通过UV,1H NMR,IR,MS,元素分析等手段对化合物进行了结构表征并初步探讨了反应机理。DNA凝胶电泳实验表明,该类光敏剂对pBR322质粒DNA具有很好的光敏切割作用,作为光敏剂或其前体具有很好的应用前景.

关键词: β-取代卟啉, 光敏剂, 合成, 表征, DNA切割

Two kinds of novel β-dihydroxyarylporphyrins were synthesized by direct reaction of β-nitroporphyrin with 2,3-dihydroxynaphthalene and o-dihydroxybenzene respectively,and structurally characterized by UV,1H NMR,IR,MS and elemental analysis。The reaction mechanism was discussed。The agarose gel electrophoresis results show that the novel compounds cause significant cleavage to pBR322 plasmid DNA,which have good application prospects as photosensitizers or their precursors.

Key words: β-nitroporphyrin, photosensitizer, synthesis, characterization, DNA cleavage

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