有机化学 ›› 2010, Vol. 30 ›› Issue (05): 731-734. 上一篇    下一篇

研究简报

1,5-苯并硫氮杂-β-内酰胺的合成及其副产物的研究

张萍1,杜彩云2,王兰芝1,李媛*,1   

  1. (1河北师范大学化学与材料科学学院 石家庄 050016)
    (2河北工程大学理学院 邯郸 056038)
  • 收稿日期:2009-08-26 修回日期:2009-11-13 发布日期:2009-12-10
  • 通讯作者: 李媛 E-mail:yuanli@mail.hebtu.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

Synthesis and By-products Studies of β-Lactam Derivatives of 1,5-Benzothiazepine

Zhang Ping1 Du Caiyun2 Wang Lanzhi1 Li Yuan*,1   

  1. (1 College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050016)
    (2 College of Science, Hebei University of Engineering, Handan 056038)
  • Received:2009-08-26 Revised:2009-11-13 Published:2009-12-10

以3-(3S-叔丁氧基)丁二酰亚胺基乙酰氯作为烯酮的来源, 和1,5-苯并硫氮杂反应合成了4个具有光学活性的新型1,5-苯并硫氮杂-β-内酰胺衍生物. 通过1H NMR, IR, MS谱和元素分析对其结构进行了表征, 在得到目标产物的同时还得到了该反应的另外两个副产物, 并且通过单晶X射线衍射确定了这两个副产物的结构.

关键词: 1,5-苯并硫氮杂, β-内酰胺, 晶体结构

Four new β-lactam derivatives of 1,5-benzothiazepine were obtained by the reaction of 3- (3S-t-butoxyl)succinimidyl acetyl chloride with 1,5-benzothiazepines and their structures were confirmed by 1H NMR, IR, MS techniques and elemental analysis. The other two products of this reaction were also obtained, and their structures were determined by X-ray diffraction analyses methods.

Key words: 1,5-benzothiazepines, β-lactam, crystal structure