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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (05): 764-767. 上一篇    下一篇

研究简报

2,4-双[3-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑-6-基]吡啶类衍生物的微波合成与结构表征  

王晓庆，赵志刚*，李伟杰，刘兴利，韩涛   

  1. (西南民族大学化学与环境保护工程学院 成都 610041)
  • 收稿日期:2009-12-30 修回日期:2010-03-10 发布日期:2010-03-24
  • 通讯作者: 赵志刚 E-mail:zzg63129@yahoo.com.cn

Synthesis and Structural Characterization of 2,4-Bis[(3-aryl)-1,2,4- triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] Derivatives of Pyridine under Microwave Irradiation

WANG Xiao-Qing, ZHAO Zhi-Gang, LI Wei-Jie, LIU Xing-Li, HAN Tao   

  1. (College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041)
  • Received:2009-12-30 Revised:2010-03-10 Published:2010-03-24
  • Contact: Zhi-Gang ZHAO E-mail:zzg63129@yahoo.com.cn

PDF

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在微波辐射下, 经三氯氧磷催化作用, 1,2,4-三唑与2,4-吡啶二甲酸反应, 高产率合成了10个未见文献报道的含双枝三唑并噻二唑稠环的吡啶类衍生物, 以期为新药筛选提供先导化合物. 所有化合物的结构均经1H NMR, IR, MS和元素分析进行了表征.

关键词: 三唑, 双三唑并[3,4-b]噻二唑, 微波, 合成

Ten novel 2,4-bis[(3-aryl)-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] derivatives of pyridine have been synthesized via reaction of 1,2,4-triazole with 2,4-pyridinedicarboxylic acid catalyzed by POCl3 under microwave irradiation, with the view of providing lead compounds for the screening of new dugs. The structures of all new compounds were characterized by 1H NMR, IR, MS techniques and elemental analysis.

Key words: triazole, bis[triazolo[3,4-b]-thiadiazole], microwave, synthesis