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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (07): 1069-1071. 上一篇    下一篇

研究简报

萘丁美酮合成的改进

陈小全*1，左之利2，仇玉芹3，周秀艳4，张昌军1，翟虎1，邵辉莹1，李保庆1   

  1. (1泰山医学院化学与化学工程学院 泰安 271000)
    (2中国科学院上海药物研究所 上海 201203)
    (3华东师范大学图书馆 上海 200062)
    (4四川大学化工学院 成都 610065)
  • 收稿日期:2009-09-08 修回日期:2009-12-06 发布日期:2010-02-11
  • 通讯作者: 陈小全 E-mail:chenxq98@163.com

Technological Improvement of Synthesis for Nabumetone

Chen Xiaoquan*1 Zuo Zhili2 Qiu Yuqin3 Zhou Xiuyan4 Zhang Changjun1 Zhai Hu1 Shao Huiying1 Li Baoqing1   

  1. (1Chemistry and Chemical Engineering School, Taishan Medical University, Taian 271000) (2Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203) (3Library, East China Normal University, Shanghai 200062) (4Chemical Engineering School, Sichuan University, Chengdu 610065)
  • Received:2009-09-08 Revised:2009-12-06 Published:2010-02-11

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1264

被引次数

5 | 1

探讨合成萘丁美酮的新方法. 以2-甲氧基萘为原料, 在超声波作用下并使用新型催化剂合成萘丁美酮. 所合成目标化合物经过IR, MS, H NMR谱确证. 通过与文献报道路线的对比, 在超声波作用下合成此药物反应时间由原先的13.5 h缩短到7.5 h, 产率由23.9%提高到39.4%. 此法在合成萘丁美酮时, 能够使合成时间缩短且产率提高.

关键词: 合成, 萘丁美酮, 超声波, 改进

In order to explore new method for synthesis of nabumetone, a synthetic method was investigated by the treatment of 2-methoxy naphthalene under ultrasonic irradiation. The time of the new synthesis method would be shortened from 13.5 h to 7.5 h and yield would be increased from 23.9% to 39.4%. The structure of the synthetic compound was identified by IR, MS and H NMR techniques.

Key words: synthesis, nabumetone, ultrasound, improvement