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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (10): 1535-1538. 上一篇    下一篇

研究简报

2-取代-5-(全氯吡啶-2-基)-1,3,4-噁二唑啉的合成及表征

沈芬芳，徐丽娟，强根荣，宋庆宝   

  1. (浙江工业大学绿色化学合成技术国家重点实验室培育基地 杭州 310014)
  • 收稿日期:2009-11-13 修回日期:2010-04-25 发布日期:2010-05-06
  • 通讯作者: 宋庆宝 E-mail:qbsong@zjut.edu.cn
  • 基金资助:

    浙江省重中之重学科开放基金和绿色化学合成技术国家重点实验室培育基地开放基金资助项目

Synthesis and Characterization of 2-Substituted-5-(perchloropyridin- 2-yl)-1,3,4-oxadiazolines Derivatives

SHEN Fen-Fang, XU Li-Juan, QIANG Gen-Rong, SONG Qing-Bao   

  1. (State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014)
  • Received:2009-11-13 Revised:2010-04-25 Published:2010-05-06

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被引次数

2

以全氯吡啶-2-甲酸为原料, 经酯化、肼解得到全氯吡啶-2-甲酰肼, 再与羰基化合物缩合得到相应的酰腙, 然后在乙酸酐作用下环合得到9个未见文献报道的2-取代-5-(全氯吡啶-2-基)-1,3,4-噁二唑啉类化合物. 所有化合物的结构均经元素分析, IR, 1H NMR, 13C NMR和MS确证.

关键词: 噁二唑啉, 全氯吡啶-2-甲酸, 酰腙, 合成

The perchloronictinic hydrazine has been prepared using esterification and hydrazinolysis of perchloropyridin-2-carboxylic acid, and then condensated with aldehydes (ketones) producing correspond hydrazones. Finally 2-substituted-5-(perchloropyridin-2-yl)-1,3,4-oxadiazolines have been obtained by the cyclodehydration of these hydrazones in acetic anhydride. Their molecule structures were characterized by elemental analysis, IR, 1H NMR, 13C NMR and MS techniques.

Key words: oxadiazoline, perchloropyridin-2-carboxylic acid, hydrazone, synthesis