有机化学 ›› 2011, Vol. 31 ›› Issue (01): 123-125. 上一篇    下一篇

研究简报

对甲苯磺酸催化研磨法合成5-芳亚甲基巴比妥酸

李记太*,孙明轩,何根业   

  1. (河北大学化学与环境科学学院 河北省分析科学技术重点实验室 保定 071002)
  • 收稿日期:2010-04-22 修回日期:2010-06-18 发布日期:2010-08-16
  • 通讯作者: 李记太 E-mail:lijitai@yahoo.com.cn
  • 基金资助:

    超声辐射下3-取代吲哚衍生物的合成及机理的研究

Synthesis of 5-Arylmethylene Barbituric Acid Catalyzed by p-Toluene Sulfonic Acid Using Grinding Method

LI Ji-Tai, SUN Ming-Xuan, HE Gen-Ye   

  1. (Key Laboratory of Analytical Science and Technology, Hebei Province, College of Chemistry and Envi-ronmental Science, Hebei University, Baoding 071002)
  • Received:2010-04-22 Revised:2010-06-18 Published:2010-08-16

在对甲苯磺酸催化下, 将芳香醛与巴比妥酸于室温研磨5~20 min, 则可得到较高收率的5-芳亚甲基巴比妥酸, 为同类化合物的合成提供了一个简便而有效的方法.

关键词: 缩合反应, 研磨, 5-芳亚甲基巴比妥酸, 合成, 无溶剂反应

Condensation of aromatic aldehydes with barbituric acid catalyzed by p-toluene sulfonic acid (PTSA) was carried out at room temperature to afford 5-arylmethylene barbituric acid in high yields within 5~20 min by grinding, providing a simple and efficient protocol for the synthesis of analogous compounds.

Key words: condensation, grinding, 5-aryliene barbituric acid, synthesis, solvent-free reaction