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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (02): 231-234. 上一篇    下一篇

研究简报

豆腐果苷-吡唑啉衍生物的合成及镇静活性研究

陈华凤1，陈华文2，白雪1，李颖1，尹述凡*,1   

  1. (1四川大学化学学院 成都 610064)
    (2四川省阿坝州黑水县维古乡卫生院 阿坝州 623504)
  • 收稿日期:2010-07-02 修回日期:2010-08-23 发布日期:2010-09-15
  • 通讯作者: 尹述凡 E-mail:chuandayouji217@163.com;;

Synthesis and Calm Activity of Helicid-Pyrazoline Derivatives

Chen Huafeng1 Chen Huawen2 Bai Xue1 Li Ying1 Yin Shufan*,1   

  1. (1 College of Chemistry, Sichuan University, Chengdu 610064)
    (2 Weigu Health Center of Heishui, Aba Autonomous Region 623504)
  • Received:2010-07-02 Revised:2010-08-23 Published:2010-09-15

PDF

1233

被引次数

10 | 2

以豆腐果苷、取代苯乙酮和4-甲氧基苯肼为原料, 设计合成了7个新型豆腐果苷-吡唑啉衍生物3a～3g, 产物结构经1H NMR, IR和HRMS予以确认. 初步生物活性测试结果表明, 部分化合物具有一定的镇静催眠活性.

关键词: 豆腐果苷-吡唑啉衍生物, 镇静活性, 合成

Seven novel helicid-pyrazoline derivatives 3a～3g were designed and synthesized via condensation of helicid, substituted hypnone and 4-methoxy-phenylhydrazine. Their chemical structures were con?rmed by 1H NMR, IR and HRMS techniques, and the calm activity was studied as well. The preliminary bioassay test showed that some of the compounds had good calm activity.

Key words: helicid-pyrazoline derivative, calm activity, synthesis