有机化学 ›› 2011, Vol. 31 ›› Issue (03): 397-400. 上一篇    下一篇

研究简报

微波辐射下离子液体催化合成α-溴代芳基酮

李德富,刘卉闵,刘伟华,袁明月,张冬暖,张英群*   

  1. (河北农业大学理学院 保定 071001)
  • 收稿日期:2010-08-12 修回日期:2010-10-29 发布日期:2010-11-12
  • 通讯作者: 张英群 E-mail:yingqun0203@163.com

Synthesis of α-Bromoarylketones Catalyzed by Ionic Liquid under Microwave Irradiation

LI De-Fu, LIU Hui-Min, LIU Wei-Hua, YUAN Ming-Yue, ZHANG Dong-Nuan, ZHANG Ying-Qun   

  1. (College of Sciences, Agricultural University of Hebei, Baoding 071001)
  • Received:2010-08-12 Revised:2010-10-29 Published:2010-11-12

在微波辐射下, 离子液体催化苯乙酮或取代苯乙酮和N-溴代丁二酰亚胺(NBS)反应合成了7种α-溴代芳基酮, 收率为73%~95%.最佳反应条件为: 甲醇为溶剂, n(芳基酮)∶n(NBS)=1∶1, 酸性离子液体MIM-PS-CH3SO3H为40 mol%, 微波辐射功率为50或250 W. 该反应时间短、产率高、环境友好、后处理方便、催化剂可重复使用. 产物的结构经 1H NMR, IR确证.

关键词: 苯乙酮, NBS, α-溴代芳基酮, 微波辐射, 离子液体

Seven α-bromoarylketones in yields of 73%~95% were obtained with ionic liquid as catalyst under microwave irradiation condition by the reaction of substituted acetophenones and N-bromosuccinim-ide. The optimal reaction conditions in methanol were as follows: n(aryl ketone)∶n(NBS)=1∶1, acidic ionic liquid MIM-PS-CH3SO3H was 40 mol%, microwave power was 50 or 250 W. The reaction easily could be worked up with short reaction time, high yields and environmental friendliness. The catalyst could be reusable. The products were identified by 1H NMR and IR spectra.

Key words: acetophenone, N-bromosuccinimide, α-bromoarylketone, microwave irradiation, ionic liq-uid