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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (04): 563-566. 上一篇    下一篇

研究简报

3-取代-6-甲氧基-7-羟基-4H-色烯-4-酮的合成及其异常反应

李涵彬，任毅，张倩*   

  1. (复旦大学药学院药物化学教研室 上海 201203)
  • 收稿日期:2010-07-16 修回日期:2010-09-16 发布日期:2010-11-29
  • 通讯作者: 张倩 E-mail:zhangqian511@shmu.edu.cn; jinww@hotmail.com

Synthesis of 3-Substituent-6-methoxy-7-hydroxy-4H-chromen-4-ones and the Related Unexpected Reactions

LI Han-Bin, REN Yi, ZHANG Qian   

  1. (Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203)
  • Received:2010-07-16 Revised:2010-09-16 Published:2010-11-29

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报道了3-位分别为苯基、氢原子以及卤素等不同取代的4H-色烯-4-酮类化合物的合成方法, 并探讨和阐明了一些意外产物的获得机理, 不仅对该位点的进一步结构改造提供了物质基础, 同时拓展了构建4H-色烯-4-酮类化合物的底物结构.

关键词: 取代4H-色烯-4-酮, 环合反应, 异常反应机理

Several 4H-chromen-4-ones with different substituents at 3-position, including phenyl, hydrogen and halogen were synthesized and the mechanism of the related unexpected products was discussed. This work will not only profit further modification on 3-position of parent structure but also enrich the chemical characteristics of this kind of compounds.

Key words: substituted 4H-chromen-4-one, cyclization, unexpected reaction