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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (05): 684-689. 上一篇    下一篇

研究论文

黄酮-6-羧酸类化合物的合成、表征和抑菌活性

温辉梁*,1，赖博文2，刘崇波3，龚云南3，陈云华2   

  1. (1南昌大学食品科学与技术国家重点实验室 南昌 330047)
    (2南昌大学理学院化学系 南昌 330031)
    (3南昌航空大学环境与化学工程学院 南昌 330063)
  • 收稿日期:2010-09-03 修回日期:2010-12-04 发布日期:2010-12-23
  • 通讯作者: 温辉梁 E-mail:hlwen70@163.com

Synthesis, Characterization and Antibacterial Activity of Six Fla-vone-6-carboxylic Acids

Wen Huiliang*,1 Lai Bowen2 Liu Chongbo3 Gong Yunnan3 Chen Yunhua2   

  1. (1 Key Laboratory of Food Science of Ministry of Education, Nanchang University, Nanchang 330047)
    (2 Department of Chemistry, Nanchang University, Nanchang 330031)
    (3 School of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063)
  • Received:2010-09-03 Revised:2010-12-04 Published:2010-12-23

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被引次数

4

通过查尔酮路线合成了6种黄酮-6-羧酸化合物, 采用I2/DMSO为氧化剂通过微波辐射合成了其中3种黄酮羧酸. 所有化合物的结构通过NMR, IR和元素分析方法进行了表征, 并采用X射线单晶衍射法进一步测定了黄酮-6,4-二羧酸的晶体结构. 初步生物活性试验结果表明, 6种化合物对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌均有一定的抑制作用.

关键词: 黄酮-6-羧酸, 合成, 表征, 晶体结构, 抑菌活性

Six flavone-6-carboxylic acid compounds were synthesized via the chalcone route, and three of them were obtained in conditions of microwave radiation using I2/DMSO as the oxidant. Their structures were characterized by NMR, IR spectra and elemental analysis, and the crystal structure of flavone-6,4-dicarboxylic acid was further determined by X-ray single crystal diffraction technique. The pre-liminary biological activity tests show that the six compounds have antibacterial activity against Echerichia coli, Staphylococcus aureus and Bacillus subtilis.

Key words: flavone-6-carboxylic acid, synthesis, characterization, crystal structure, antibacterial activity