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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (05): 690-694. 上一篇    下一篇

研究论文

基于MCM-41微反应器的微波辅助合成新方法研究

肖尚友*，杨昊书，李倩倩，邱静，夏之宁   

  1. (重庆大学化学化工学院 重庆 400030)
  • 收稿日期:2010-09-05 修回日期:2010-12-07 发布日期:2010-12-23
  • 通讯作者: 肖尚友 E-mail:xsy6508@163.com

Investigation on Novel Microwave-Assisted Synthesis Method Based on MCM-41 Microreactor

XIAO Shang-You, YANG Hao-Shu, LI Qian-Qian, QIU Jing, XIA Zhi-Ning   

  1. (College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030)
  • Received:2010-09-05 Revised:2010-12-07 Published:2010-12-23

PDF

1436

被引次数

12

采用微波辐射合成法合成了纳米介孔分子筛MCM-41作为微反应器. 以苯并呋喃-2(3H)-酮的合成为实例, 在甲苯介质中将邻羟基苯乙酸组装到MCM-41微反应器中, 研究了溶液体系及微反应器中反应温度、反应时间及微波辐射时间对反应的影响. 结果显示, 在施加微波与不施加微波情况下, MCM-41微反应器中进行的反应较溶液体系中进行的反应产率提高了2～33与2～12倍. 对于MCM-41微反应器中的反应, 施加微波辐射后反应产率可进一步提高20%～100%.

关键词: MCM-41, 微反应器, 邻羟基苯乙酸, 苯并呋喃-2(3H)-酮

MCM-41 mesoporous molecular sieve was synthesized under microwave irradiation and used as microreactor. 2-Hydroxyphenylacetic acid was assembled into MCM-41 microreactor in toluene solution, and benzofuran-2(3H)-one was obtained by the intramolecular esterification of 2-hydroxyphenylacetic acid with high selectivity. The reaction conditions including temperature, reaction time, microwave iradiation and so on were investigated. The yield of benzofuran-2(3H)-one was im-proved by 2～12 and 2～33 times in MCM-41 microreactor than that in solution under conventional heating and microwave irradiation respectively. In addition, the yield of the reaction in MCM-41 reactor under mi-crowave irradiation could be improved by 20%～100%.

Key words: MCM-41, microreactor, 2-hydroxyphenylacetic acid, benzofuran-2(3H)-one