有机化学 ›› 2016, Vol. 36 ›› Issue (11): 2662-2669.DOI: 10.6023/cjoc201604038 上一篇    下一篇

研究论文

连续流微反应器中CuCN-TsOH催化合成2-芳基-4,5-二氢-1H-咪唑啉

周俊杰, 唐志珂, 张超, 王洞天, 张开, 孙宏滨   

  1. 东北大学化学系 沈阳 110819
  • 收稿日期:2016-04-18 修回日期:2016-06-19 发布日期:2016-07-13
  • 通讯作者: 孙宏滨 E-mail:sunhb@mail.neu.edu.cn

CuCN-TsOH Catalyzed Synthesis of 2-Aryl-4,5-dihydro-1H-imidazoline in a Continuous-Flow Microreactor

Zhou Junjie, Tang Zhike, Zhang Chao, Wang Dongtian, Zhang Kai, Sun Hongbin   

  1. Department of Chemistry, Northeastern University, Shenyang 110819
  • Received:2016-04-18 Revised:2016-06-19 Published:2016-07-13

应用连续流微反应器,以CuCN-TsOH为催化剂,通过腈和乙二胺反应合成了一系列2-咪唑啉类化合物.催化剂CuCN-TsOH在乙二胺中溶解成均相,适用于连续化反应条件.在连续流条件下,只需5 min就可以高产率得到2-咪唑啉产物.利用连续流反应器实现了“在线保留时间梯度(in-tube retention time gradient,IT-RTG)”,并应用于监测反应进程.

关键词: 连续流微反应器, 2-咪唑啉, 催化, 氰化亚铜, 腈, 环合

2-Imidazolines were synthesized via CuCN-TsOH catalyzed cyclization of nitriles with ethylenediamine in a continuous-flow microreactor. The CuCN-TsOH dissolves in ethylenediamine homogeneously and is a suitable catalyst for the continuous reactions. Under the flow condition, the 2-imidazolines were obtained with high yields in 5 min for most substrates. The "in-tube retention time gradient" (IT-RTG) is achieved in the continuous-flow microreactor, and it is applied in monitoring the reaction progress.

Key words: continuous-flow microreactor, 2-imidazoline, catalysis, cuprous cyanide, nitrile, cyclization