有机化学 ›› 2011, Vol. 31 ›› Issue (05): 695-700. 上一篇    下一篇

研究论文

N-3烷基取代嘧啶及其衍生物的合成

牛红英*,1,2,张晓婷1,赵改云1,李宁1,孔思楠1,夏超1,渠桂荣1,郭海明*,1   

  1. (1河南师范大学化学与环境科学学院 新乡 453007)
    (2河南科技学院化学化工学院 新乡 453003)
  • 收稿日期:2010-09-26 修回日期:2010-12-09 发布日期:2010-12-23
  • 通讯作者: 郭海明 E-mail:ghm@htu.cn

Synthesis of N-3 Alkylation of Pyrimidine and Its Derivatives

Niu Hongying*,1,2 Zhang Xiaoting1 Zhao Gai-yun1 Li Ning1 Kong Sinan1 Xia Chao1 Qu Guirong1 Guo Haiming*,1   

  1. (1 College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007)
    (2 School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003)
  • Received:2010-09-26 Revised:2010-12-09 Published:2010-12-23
  • Contact: Hai-Ming GUO E-mail:ghm@htu.cn

在室温条件下, 经过三步反应, 合成了一系列N-3烷基取代的嘧啶类化合物. 该方法具有条件温和、操作简便、反应时间短、产率高等特点. 目标产物经过了1H NMR, 13C NMR和MS确证表征.

关键词: 嘧啶, N-3烷基化, 合成

An easy and efficient synthesis of 3-alkylpyrimidines is described. Thus, Boc-protection at N-1 of uracil permits selective alkylation at N-3. This protecting group can be removed under very mild conditions. The products were identified by 1H NMR, 13C NMR and MS techniques.

Key words: pyrimidine, N-3 alkylation, synthesis