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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (06): 860-864. 上一篇    下一篇

研究简报

无催化剂条件下微波辐射一步法合成2-氨基-4-芳基-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-腈

栾长军1，王建强1，张国华1，王伟1，唐拾贵2，郭成*,1   

  1. (1南京工业大学理学院 南京 210009)
    (2南京工业大学生物与制药工程学院 南京 210009)
  • 收稿日期:2010-08-10 修回日期:2010-10-10 发布日期:2011-01-11
  • 通讯作者: 郭成 E-mail:guocheng@njut.edu.cn

One-pot synthesis of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles under microwave irradiation without the catalyst

Luan Changjun1 Wang Jianqiang1 Zhang Guo-hua1 Wang Wei1 Tang Shigui2 Guo Cheng*,1   

  1. (1 College of Science, Nanjing University of Technology, Nanjing 210009)
    (2 Biotechnology and Pharmaceutical Engineering, Nanjing University of Technol-ogy, Nanjing 210009)
  • Received:2010-08-10 Revised:2010-10-10 Published:2011-01-11
  • Contact: Cheng Guo E-mail:guocheng@njut.edu.cn

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1169

被引次数

9 | 4

以芳醛、丙二腈、1,3-环己二酮为原料在无催化剂条件下, 分别用微波辐射和传统加热法合成了一系列2-氨基-4-芳基-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-腈(4a～4g)衍生物. 与常规加热方法相比, 微波辐射法具有反应时间短、产率高、后处理方便、环境友好等优点, 所有化合物均经IR,1H NMR和元素分析确定.

关键词: 芳醛, 丙二腈, 1,3-环己二酮, 苯并吡喃, 微波

A series of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives (4a～4g) were prepared by using 1,3-cyclohexanedione, aromatic aldehydes and malononitrile in anhydrous alcohol under microwave irradiation without catalyst. Compared with conven-tional heating method, the method of microwave irradiation possesses advantages including short time, high yield and environmental friendliness, etc. The structures of these compounds were characterized by IR, 1H NMR spectra and elemental analysis.

Key words: aromatic aldehyde, malononitrile, 1,3-cyclohexanedione, benzopyran, microwave irradiation