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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (11): 1965-1970. 上一篇    下一篇

研究论文

5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶双杂环衍生物的合成与生物活性

马忠华a,b; 刘祖明b; 陈 琼*,b   

  1. (a华中农业大学理学院 武汉 430070)
    (b华中师范大学农药与化学生物学教育部重点实验室 武汉 430079)
  • 收稿日期:2008-03-04 修回日期:2008-04-27 发布日期:2008-11-18
  • 通讯作者: 陈 琼

Synthesis and Biological Activity of Diheterocyclic 5,7-Dimethyl-1,2,4- triazolo[1,5-a]pyrimidine Derivatives

MA, Zhong-Hua a,b; LIU, Zu-Ming b; CHEN, Qiong*,b   

  1. (a College of Basic Sciences, Huazhong Agricultural University, Wuhan 430070)
    (b Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry,
    Central China Normal University, Wuhan 430079)
  • Received:2008-03-04 Revised:2008-04-27 Published:2008-11-18
  • Contact: CHEN, Qiong

PDF

1230

被引次数

34

以2-巯基-5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶为原料, 设计合成了17种含5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶环和1,2,4-三唑环的新型双杂环化合物, 结构经元素分析, MS, 1H NMR及13C NMR进行表征. 初步的生物活性测试表明, 部分化合物表现出较好的杀菌、除草活性.

关键词: 1,2,4-三唑并[1,5-a]嘧啶, 1,2,4-三唑, 合成, 生物活性

Seventeen novel diheterocyclic compounds containing 1,2,4-triazolo[1,5-a]pyrimidine and 1,2,4-triazole moieties were designed and synthesized by using 2-mercapto-5,7-dimethyl-1,2,4-triazolo[1,5-a]- pyrimidine as starting materials. All compounds obtained were confirmed by elemental analyses, MS, 1H NMR and 13C NMR spectra. Preliminary biological activity indicated that some of them displayed good fungicidal and her-bicidal activities.

Key words: 1,2,4-triazole, 1,2,4-triazolo[1,5-a]pyrimidine, synthesis, biological activi