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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (11): 1997-2000. 上一篇    下一篇

研究简报

N-(5-邻氯苯基-2-呋喃甲酰氨基)丙氨酰胺衍生物的合成和 生物活性测定

胥 杨; 薛思佳*; 孙晋峰; 方治坤; 尹安琴; 陈 龙   

  1. (上海师范大学生命与环境科学学院化学系 上海 200234)
  • 收稿日期:2008-02-01 修回日期:2008-04-23 发布日期:2008-11-18
  • 通讯作者: 薛思佳

Synthesis and Biological Activity of N-[5-(2-Chlorophenyl)furan-2- formylamino]alanamide Derivatives

XU, Yang; XUE, Si-Jia* ; SUN, Jin-Feng; FANG, Zhi-Kun; YIN, An-Qin ; CHEN, Long
  

  1. (a Department of Chemistry, Shanghai Normal University, Shanghai 200234)
  • Received:2008-02-01 Revised:2008-04-23 Published:2008-11-18
  • Contact: XUE, Si-Jia

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被引次数

1

以5-邻氯苯基-2-呋喃甲酰氯和丙氨酸为起始原料, 通过非均相法得到N-(5-邻氯苯基-2-呋喃甲酰氨基)丙氨酸, 再与10种不同取代苯胺反应, 通过N,N’-二环己基碳二亚胺和4-二甲氨基吡啶(DCC/DMAP)偶合法设计合成了10个未见文献报道的N-(5-邻氯苯基-2-呋喃甲酰氨基)丙氨酰胺类衍生物4a～4j. 通过元素分析, 1H NMR, IR 和MS确定化合物的结构, 初步生物活性测试表明标题化合物具有一定的除草活性.

关键词: 5-邻氯苯基-2-呋喃甲酰氯, 酰胺, 衍生物合成, 除草活性
, 丙氨酸

N-[5-(2-Chlorophenyl)furfuroyl]alanine was prepared by taking 5-(2-chlorophenyl)furfuroyl chloride and alanine as raw materials via a nonhomogeneous reaction. Ten unreported N-[5-(2-chloro- phenyl)furan-2-formylamino]alanamide derivatives (4a～4j) were designed and synthesized by using a DCC/DMAP coupling method with N-[5-(2-chlorophenyl)furfuroyl]alanine and 10 differently substituted anilines. The structures of the target compounds were confirmed by MS, IR, 1H NMR spectra, and elemental analysis. The preliminary biological tests show that some of the target compounds have certain herbicidal activities.

Key words: 5-(2-chlorophenyl)furfuroyl chloride, herbicidal activi, amide, derivative synthesis, alanine