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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (12): 2159-2161. 上一篇    下一篇

研究简报

N-硫脲基套索杯[4]冠醚与四硫脲基杯[4]芳烃的合成

郑小花 ;杨发福*; 唐富胜; 殷凤菊; 杨严心   

  1. (福建师范大学化学与材料学院 福州 350007)

  • 收稿日期:2008-05-04 修回日期:2008-06-10 发布日期:2008-12-28
  • 通讯作者: 杨发福

Synthesis of N-Thioureido Lariat Calix[4]crown and Calix[4]arene Tetrathioureido Derivatives

ZHENG, Xiao-Hua; YANG, Fa-Fu*; TANG, Fu-Sheng; YIN, Feng-Ju ; YANG, Yan-Xin   


  1. (College of Chemistry and Materials, Fujian Normal University, Fuzhou 350007)
  • Received:2008-05-04 Revised:2008-06-10 Published:2008-12-28
  • Contact: YANG, Fa-Fu

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1568

被引次数

4

控制反应物的物质的量比, 杯式对叔丁基杯[4]-1,3-二乙酸乙酯衍生物1与5或50倍二乙烯三胺反应, 分别得到杯[4]氮杂冠醚2和开链的氮杂杯[4]芳烃衍生物3. 化合物2和3进一步与异硫氰酸苯酯反应得到首例侧链含硫脲基的套索杯[4]氮杂冠醚4和含4个硫脲基的杯[4]芳烃衍生物5, 产率为92%和87%. 新化合物的结构与构象经元素分析、红外、质谱、核磁共振谱等表征证实.

关键词: 杯[4]冠醚, 硫脲, 套索, 合成, 杯[4]芳烃

Under control of the molar ratio of reactants, calix[4]-aza-crown 2 and ring-opening aza- calix[4]arene derivative 3 were obtained by reacting 5 or 50 times diethylene triamine with calix[4]arene ester derivative 1. Reacting compound 2 or 3 with phenyl isothiocyanate, novel N-thioureido lariat calix[4]crown 4 and calix[4]arene tetrathioureido derivative 5 were synthesized in yields of 92% and 87%, respectively. The structures and conformations of new compounds were characterized by elemental analyses, IR, ESI-MS, 1H NMR etc.

Key words: calix[4]crown, synthes, thiourea, lariat, calix[4]arene