有机化学 ›› 1999, Vol. 19 ›› Issue (6): 621-624. 上一篇    下一篇

研究论文

光化疗抑瘤剂四苯基卟吩氮芥的合成

陈志龙;蔡建明;许德余   

  1. 第二军医大学海医系;第二军医大学防化医学研究所
  • 发布日期:1999-12-25

Synthesis of meso-tetra(substituted phenyl)porphin nitrogen mustards possessing anti-tumor activities in chemotherapy and photodynamic therapy

Chen Zhilong;Cai Jianming;Xu Deyu   

  • Published:1999-12-25

首次报道合成了6个四苯基卟吩氮芥化合物,其结构均经波谱及元素分析确证,活性实验表明所有受试化合物均具有对人肝癌细胞株SMMC-7721的化学杀伤和光动力效应双重活性,具有发展为高效低毒光化抗肿瘤药物的前景。

关键词: 合成, 抗肿瘤药, 光动力效应, 光化疗法, 表征, 氮芥化合物, 卟吩P, 苯基

Six meso-tetra(substituted phenyl)porphin nitrogen mustards were synthesized for the first time. All these compounds possess both chemotherapeutic and photodynamic effects on tumor and deserve further investigation.

Key words: PORPHINE P, PHOTOCHEMICAL THERAPY, CHARACTERIZATION, PHENYL GROUP, ANTITUMOR DRUGS, SYNTHESIS, MUSTARD COMPOUND

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