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有机化学
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有机化学 ›› 1992, Vol. 12 ›› Issue (3): 260-263. 上一篇    下一篇

研究论文

5'-脱氧-5'-氟-5-氟尿核苷的合成和性质

曾福金;周瑾;陈耀全   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1992-06-25

Synthesis and properties of 5'-deoxy-5'-fluoro-5-fluorouridine

ZENG FUJIN;ZHOU JIN;CHEN YAOQUAN   

  • Published:1992-06-25

被引次数

3 | 1

叙述了5'-脱氧-5'-氟尿核苷和5'-脱氧-5'-氟-5-氟尿核苷的合成, 并比较了它们以及尿核苷和5-氟尿核苷的一些性质。

关键词: 尿核苷, 核苷, 氟尿核苷, 影响, 反应速度, 氟, 有机氟化合物, 核磁共振谱法

The title compound (I; R = R1 = F) (II) was prepared in 4 steps starting from I (R = OH, R1 = F). The properties of II e.g., H1 NMR, the reaction rate of isopropylidenation and deisopropylidenation were investigated in comparison with uridine (I; R = OH, R1 = H).

Key words: INFLUENCE, FLUORINE, NUCLEOSIDE, NMR SPECTROMETRY, REACTION RATE, ORGANO FLUORINE COMPOUNDS

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