有机化学 ›› 2003, Vol. 23 ›› Issue (2): 173-175. 上一篇    下一篇

研究论文

一个新的制备咪唑并[1,5-α]吡啶衍生物的串联反应

王建武;贾炯;候殿杰;李红梅;尹军   

  1. 山东大学化学与化工学院,济南(250100)
  • 发布日期:2003-02-25

A novel tandem reaction to synthesize imidazo [l ,5-α] pyridine derivatives

Wang Jianwu;Jia Jiong;Hou Dianjie;Li Hongmei;Yin Jun   

  1. School of Chemistry and Chemical Enginnering,Shandong University, Jinan(250100)
  • Published:2003-02-25

发现5-咪唑甲醛(1)与γ-溴代巴豆酸酯(2)在弱碱条件下首先进行亲核 取代反应生成3,继而生成γ-碳负离子并转移到α-位,然后进行了分子内亲核 进攻成环,脱水生成4的串联反应,提供了一个合成咪唑并[1,5-α]吡啶-7-羧 酸酯衍生物的新方法。

关键词: 吡唑 P, 吡啶 P, 亲核反应, 羧酸酯

An unusual intramolecular nucleophilic reaction of a-carbon anion of crotonate was discovered and the imidazo[ 1, 5-a ] pyridine derivatives were sythesized with a novel tandem reaction. The reaction mechanism was discussed.

Key words: PYRAZOLE P, PYRIDINE P, NUCLEOPHILIC REACTION, CARBOXYLIC ACID ESTER

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