有机化学 ›› 2003, Vol. 23 ›› Issue (3): 270-273. 上一篇    下一篇

研究论文

冬凌草中的新对映-贝壳杉烷二萜化合物

韩全斌;梅双喜;姜北;赵爱华;孙汉黄   

  1. 中国科学院昆明植物研究所
  • 发布日期:2003-03-25

New ent-kaurane diterpenoids from isodon rubescens

Han Quanbin;Mei Shuangxi;Jiang Bei;Zhao Aihua;Sun Handong   

  1. State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences
  • Published:2003-03-25

对河南省济源地区产冬凌草[Isodon rubescens(Hemsl.)Hara]再次进行了深入 的研究,从其叶的乙酸乙酯提取物中分离得到了16个化合物,其中1和2为两个新的 7,20-环氧-对映-贝壳杉烷类二萜化合物,其结构通过波谱分析确定为16(S)-羟 甲基-1α,6β,7β,11β-甲羟基-7α,20-环氧-对映-贝壳杉烷-15-酮(1)和 16(R)-羟甲基-1α,6β,7β,14β-四羟基-7α,20-环氧-对映-贝壳杉烷-15- 酮(2),分别命名为冬凌草已素(1)和庚素(2);其余的已知化合物分别鉴定 为lasiodonin(3),冬凌草甲素(oridonin,4),乙素(ponicidin),丙素( rubescensin C),丁素(rubescensin D),牛尾草丙素(rabdoternin C),荛 花香茶菜乙素(wikstroemioidin B),enmenol-1α-O-β-D-glucoside, enmenol,胡麻素(pedalitin),水杨酸,乌索酸,β-谷甾醇和胡萝卜甙。

关键词: 冬凌草, 二萜, 甾醇, 化学成分

Two new ewi-kaurane diterpenoids, 16 ( S)-hydroxymethyl-la , 6β, 7 β, llβ-tetrahydroxy-7a , 20-epoxy-eni-kauran-15-one (1) and 16 ( R )- hydroxymethyl-la , 6β, 7β, 14βtetrahydroxy-7a , 20-epoxy-enf-kauran- 15-one (2) , named rubescensins F (1) and G (2) , respectively, were isolated from the EtOAc extract of the dried leaves of hodon rubescens (Hemsl.) Kara collected in Jiyuan Prefecture, Henan Province, together with fourteen known compounds lasiodonin (3), oridonin (4) , ponicidin, rubescensins C and D, rabdoternin C, wikstroemioidin B, enmenol-la-0-β -.D-glucoside, enmenol, pedalitin, salicylic acid, ursolic acid, β sitosterol and daucosterol. Their structures were determined on the basis of spectral data.

Key words: RABDOSIA RUBESCENS (HEMSL) HARA, DITERPENES, STEROL, CHEMICAL COMPOSITION

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