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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (5): 475-478. 上一篇    下一篇

研究论文

二{氧合-二[2-呋喃甲酸二苄基锡（IV)]}的合成、性质及晶体结构

尹汉东;王传华;马春林   

  1. 聊城大学化学系
  • 发布日期:2003-05-25

Synthesis, Anti-tumour Properties and Crystal Structure of Bis { oxo-bis[ (2-furylcarboxylato)dibenzyltin(IV) ]}

Yin Handong;Wang Chuanhua;Ma Chunlin   

  1. Department of Chemistry,Liaocheng University
  • Published:2003-05-25

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以二苄基氧化锡和2-呋喃基羧酸反应，合成了新的化合物二[氧合-二[2—呋喃 甲酸二苄基锡(IV)]}．生物活性测试结果表明，该配合物具有较强的体外抗癌活性 ．X射线单晶衍射测定表明，配合物是以Sn2O2四元环为中心的、中心对称的二聚体 结构，内环锡为六配位的畸变八面体结构，外环锡为五配位的加帽畸变三角双锥结 构．

关键词: 晶体结构, 呋喃甲酸 P, 有机锡化合物, 抗癌药, 生物活性

Bis { oxo-bis [ (2-furylcarboxylato ) dibenzyltin (IV) ] } was synthesized by the reaction of 2-furylcarboxylic acid with the (PhCH2) 2SnO. The compound was tested against two human tumour cell lines: MCF- 7 and WiDr. The results showed that this compound had higher activities in vitro. The crystal structure was determined by X-ray diffraction study. The compound possesses centrosymmetric dimer structure mode with a four-member central endo-cyclic Sn2O2 unit in which the bridged oxygen atoms are tri-coordinated. Each bridged oxygen atom also connects with an era-cyclic tin atom. The endo-cyc\ic tin atoms are six-coordination and have coordination geometry of distorted octahedron. The ew-cyclic tin atoms are five-coordinate and have coordination geometry of monocapped trigonal bipyramid with very similarly distorted mode.

Key words: CRYSTAL STRUCTURE;FURANCARBOXYLIC ACID P;ORGANO TIN COMPOUNDS, ANTICARCINOGEN;BIOLOGICAL ACTIVITY

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