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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (06): 758-762. 上一篇    下一篇

研究论文

3-芳氧基-6-(3,5-二甲基-1H-吡唑-1-基)哒嗪的合成及生物活性

胡方中，张桂峰，朱有全，邹小毛，刘斌，杨华铮*   

  1. (南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2006-08-14 修回日期:2006-10-16 发布日期:2007-05-21
  • 通讯作者: 杨华铮

Synthesis and Biological Activity of 3-Aryloxy-6-(3,5-dimethyl- 1H-pyrazol-1-yl)-pyridazine

HU Fang-Zhong, ZHANG Gui-Feng, ZHU You-Quan, ZOU Xiao-Mao
LIU Bin, YANG Hua-Zheng*   

  1. (State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry,
    Nankai University, Tianjin 300071)
  • Received:2006-08-14 Revised:2006-10-16 Published:2007-05-21
  • Contact: YANG Hua-Zheng

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为了寻找高活性的先导化合物, 以3,6-二氯哒嗪为原料, 经过三步反应, 合成了一系列未经文献报道的3-芳氧 基-6-(3,5-二甲基-1H-吡唑-1-基)哒嗪. 所有新化合物的结构均经过1H NMR, IR, LC-MS和元素分析确认. 初步的生物活性测试表明, 所合成的化合物都有一定的除草活性.

关键词: 吡唑, 合成, 生物活性, 哒嗪

In order to find highly active lead compounds, a series of new pyridazine derivatives have been synthesized using 3,6-dichloropyridazine as starting material by a three-step synthetic route. The structures of all compounds were confirmed by 1H NMR, IR, LC-MS spectra and elemental analyses. The preliminary bioassay results showed that all of the compounds possessed some extent herbicidal activity.

Key words: pyrazole, synthesis, biological activity, pyridazine