SIOC English
有机化学
高级检索

有机化学 ›› 2009, Vol. 29 ›› Issue (06): 979-984. 上一篇    下一篇

研究简报

三组分一锅法合成3-(2-喹啉基)薁甲酸甲酯衍生物

孙曙光 ; 谷 峥; 王道林* ; 韩 珊 黄孝东   

  1. (渤海大学化学化工学院 辽宁省应用化学重点实验室 锦州 121003)
  • 收稿日期:2008-07-14 修回日期:2008-10-23 发布日期:2009-06-20
  • 通讯作者: 王道林

Three Component One-Pot Synthesis of Methyl 3-(2-Quinolyl)azulene-1-carboxylates

Sun, Shuguang ; Gu, Zheng ; Wang, Daolin* ; Han, Shan ; Huang, Xiaodong   

  1. (Liaoning Key Laboratory of Applied Chemistry, College of Chemistry and Chemical Engineering,
    Bohai University, Jinzhou 121003)
  • Received:2008-07-14 Revised:2008-10-23 Published:2009-06-20
  • Contact: Wang, Daolin

PDF

1272

被引次数

9 | 4

在质子酸作用下, 以1-甲酰基薁-3-甲酸甲酯、芳香胺和脂肪醛为原料, 三组分一锅法合成了一系列3-(2-喹啉基)薁甲酸甲酯衍生物. 该反应收率良好、操作简单、条件温和. 产物的结构通过红外光谱、核磁共振谱和元素分析证实, 同时给出了该反应可能的反应机理.

关键词: 1-甲酰基薁, 3-(2-喹啉基)薁, 合成, 薁

Methyl 3-(2-quinolyl)azulene-1-carboxylate derivatives were synthesized by three component one-pot condensation of methyl 1-formoylazulene-3-carboxylate, aromatic amines and alkylaldehydes under mild conditions. This method provides several advantages such as good yield and simple work-up procedure. All the products were fully characterized by 1H NMR, IR spectra and elemental analysis.

Key words: 1-formoylazulene-3-carboxylate, 3-(2-quinolyl)azulene, synthesi, azulene