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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (06): 989-992. 上一篇    下一篇

研究简报

1-氮杂环-2-(6-甲氧基萘-2-基)丙-2-醇的合成、表征与生物活性

陈 平a ; 王 宇b,c ; 胡艾希*,b ; 张建宇b,c ; 于正英b ; 欧晓明c   

  1. (a长沙理工大学化学与生物工程学院 长沙 410004)
    (b湖南大学化学化工学院 长沙 410082)
    (c国家农药创制工程技术研究中心 长沙 410007)
  • 收稿日期:2008-10-24 修回日期:2008-12-10 发布日期:2009-06-20
  • 通讯作者: 胡艾希

Synthesis, Characterization and Bioactivity of 1-Nitrogenous Heterocyclic-2-(6-methoxynaphth-2-yl)propan-2-ol

Chen, Pinga ; Wang, Yu b,c ; Hu, Aixi*,b ; Zhang, Jianyu b,c ;
Yu, Zhengyingb; Ou, Xiaomingc
  

  1. (a College of Chemical and Biological Engineering, Changsha University of Science and Technology, Changsha 410004)
    (b College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)
    (c National Engineering Research Center for Agrochemicals, Changsha 410007)
  • Received:2008-10-24 Revised:2008-12-10 Published:2009-06-20
  • Contact: Hu, Aixi

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被引次数

9 | 3

6-甲氧基-2-萘基乙酮经硫酸单酯三甲锍环氧化和氮杂环开环反应, 合成了4种新的唑类化合物. 目标物经核磁共振和MS测定其结构; 分析目标物中萘环质子偶合分裂情况, 并确定萘环上各质子的归属. 生物活性测试结果表明, 部分新化合物具有杀菌活性.

关键词: 合成, 表征, 生物活性
, 唑类化合物

Four novel 1-nitrogenous heterocyclic-2-(6-methoxynaphth-2-yl)propan-2-ols were synthesized by epoxidation and ring-opening reaction from 1-(6-methoxynaphth-2-yl)ethanones. Their structures were established by MS and 1H NMR data. Proton assignment of naphthyl was determined by analyzing coupling fission constants on the naphthyl of the target compound. The preliminary bioassays indicated that some compounds showed fungicidal activities.

Key words: synthesis, characterization, bioactivi, nitrogenous heterocycle