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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (08): 981-984. 上一篇    下一篇

研究论文

6-芳氧基-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性的研究

邹燕a，吴凯群a，杨祖幸a，王玉良*,a，侯太平b，陈淑华a   

  1. (a四川大学化学学院 成都 610064)
    (b四川大学生命科学学院 成都 610064)
  • 收稿日期:2006-10-08 修回日期:1900-01-01 发布日期:2007-07-30
  • 通讯作者: 王玉良*

Study on the Synthesis and Anticoccidial Activity of Ethyl 6-Aryloxy-4-hydroxy-3-quinolinecarboxylates

ZOU Yana, WU Kai-Quna, YANG Zu-Xinga, WANG Yu-Liang*,a
HOU Tai-Pingb CHEN Shu-Huaa   

  1. (a College of Chemistry, Sichuan University, Chengdu 610064)
    (b College of Life Science, Sichuan University, Chengdu 610064)
  • Received:2006-10-08 Revised:1900-01-01 Published:2007-07-30
  • Contact: WANG Yu-Liang*

PDF

932

被引次数

16 | 3

设计并合成了8个新的6-芳氧基-4-羟基-3-喹啉羧酸乙酯类化合物. 合成路线短, 产率高, 原料易得, 易实现工业化. 所有化合物的结构均经1H NMR, MS, IR和元素分析所证实. 并选择了其中3个化合物进行抗球虫活性实验, 结果表明. 化合物6-(2-甲氧苯氧基)-4-羟基-3-喹啉羧酸乙酯具有抗球虫效果, 并有可能作为抗球虫药物使用.

关键词: 4-羟基-3-喹啉羧酸乙酯, 合成, 抗球虫活性

Eight ethyl 6-aryloxy-4-hydroxy-3-quinolinecarboxylates have been designed and synthesized. The new process is characterized by short synthetic route, high yield and cheap raw materials, which is convenient for the commercial production. Structures of the new compounds have been confirmed by 1H NMR, MS, IR spectra and elemental analysis. Three of the new compounds were chosen for the anticoccidial activity test and the result had shown that ethyl 4-hydroxy-6-(2-methoxyphenoxy)-3-quinolinecarboxylate (4f) has anticoccidial activity and can be used as an anticoccidial medicine.

Key words: synthesis, anticoccidial activity, ethyl 6-aryloxy-4-hydroxy-3-quinolinecarboxylate