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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (08): 1232-1235. 上一篇    下一篇

研究论文

六氢哒嗪衍生物的合成与生物活性研究

杜晓华*,a ; 胡丽华a; 孙祖光a; 聂思桥b ; 徐振元a   

  1. (a浙江工业大学催化加氢研究中心 杭州 310014)
    (b湖南化工研究院 长沙 410082)
  • 收稿日期:2008-10-18 修回日期:2008-12-30 发布日期:2009-08-30
  • 通讯作者: 杜晓华

Synthesis and Bioactivities of Hexahydropyridazine Derivatives

Du, Xiaohua*,a; Hu, Lihuaa; Sun, Zuguang a;Nie, Siqiao b; Xu, Zhenyuana   

  1. (a Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou 310014)
    (b Hunan Research Institute of Chemical Industry, Changsha 410082)
  • Received:2008-10-18 Revised:2008-12-30 Published:2009-08-30
  • Contact: Du, Xiaohua

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1186

被引次数

2 | 2

以六氢哒嗪为先导化合物, 合成了13个新型六氢哒嗪衍生物, 通过IR, 1H NMR和MS进行了结构表征, 对其中3个代表性的化合物培养了单晶, 获得了X射线衍射结构. 初步的生测结果表明部分化合物具有除草活性.

关键词: 六氢哒嗪, 除草活性, 氨基甲酰基六氢哒嗪, 合成, 三唑并哒嗪

Thirteen novel hexahydropyridazine derivatives were synthesized based on hexahydropyridazine. And structurally confirmed by IR, 1H NMR and mass spectra. The crystal structures of 1a, 2a and 3a were determined by X-ray diffraction analysis. Preliminary bioassays show that some of the compounds have her-bicidal activities.

Key words: 1,2,4-triazolo[1,2-a]pyridazine, synthesis, hexahydropyridazine-1-carboxamide, herbicidal activi, hexahydropyridazine